Microdialysis: use in human exercise studies

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Microdialysis: use in human exercise studies.

Microdialysis has been used for 25 years to study brain function in vivo. Recently, it has been developed for investigations on peripheral tissues. A microdialysis catheter is an artificial blood vessel system which can be placed in the extracellular space of various tissues such as adipose tissue and skeletal muscle in order to examine these tissues in situ. Molecules are collected from the ti...

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Brain microdialysis in exercise research.

During the last 5 to 10 years, the microdialysis technique has been used to explore neurotransmitter release during exercise. Microdialysis can collect virtually any substance from the brains of freely moving animals with a limited amount of tissue trauma. It allows the measurement of local neurotransmitter release in combination with ongoing behavioural changes such as exercise. Several groups...

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Use of microdialysis in translational pharmacological research

Kehr Jan*, Takashi Yoshitake, Bengt Dahlström, Folke Sjöberg 1 Pronexus Analytical AB, Grindstuvägen 44, 167 33 Bromma, Sweden. 2 Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz väg 2, 171 77 Stockholm, Sweden. 3 CTC Clinical Trial Consultants AB, Sveavägen 8, 752 36 Uppsala, Sweden. 4 Department of Clinical and Experimental Medicine, Faculty of Health Sciences, L...

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Lipolysis in human adipose tissue during exercise: comparison of microdialysis and a-v measurements.

Subcutaneous adipose tissue lipolysis was studied in vivo by Fick's arteriovenous (a-v) principle using either calculated (microdialysis) or directly measured (catheterization) adipose tissue venous glycerol concentration. We compared results during steady-state (rest and prolonged continuous exercise), as well as during non-steady-state (onset of exercise and early exercise) experimental setti...

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Interstitial K(+) in human skeletal muscle during and after dynamic graded exercise determined by microdialysis.

Interstitial K(+) concentrations were measured during one-legged knee-extensor exercise by use of microdialysis with probes inserted in the vastus lateralis muscle of the subjects. K(+) in the dialysate was measured either by flame photometry or a K(+)-sensitive electrode placed in the perfusion outlet. The correction for fractional K(+) recovery was based on the assumption of identical fractio...

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ژورنال

عنوان ژورنال: Proceedings of the Nutrition Society

سال: 1999

ISSN: 0029-6651,1475-2719

DOI: 10.1017/s0029665199001214